Select the bottom-to-top sequence of phases in the tissue healing pyramid.

• A. Late Remodeling → Inflammation → Early Remodeling
• B. Inflammation → Early Proliferation → Late Proliferation → Early Remodeling → Late Remodeling
• C. Early Proliferation → Inflammation → Late Remodeling
• D. Inflammation → Early Remodeling → Late Proliferation → Early Proliferation → Late Remodeling

Answer: (B)

Healing progresses in stages from the initial response to maturation, and the timeline moves from inflammation to proliferation and finally to remodeling. Inflammation is the first response after injury, kicking off hemostasis and immune cell activity to clean debris and protect the area. After that foundational step, the tissue enters the proliferation phase, where early activities like granulation tissue formation and new blood vessel growth begin and then progress to later changes driven by fibroblasts and collagen deposition to close the wound. The process then shifts to remodeling, starting with early remodeling as the newly laid matrix is reorganized, and continuing to late remodeling where realignment and strengthening of the tissue occur over time. This bottom-to-top sequence— inflammation, early proliferation, late proliferation, early remodeling, late remodeling—fits the natural biological order most precisely. Sequences that place remodeling before proliferation or disrupt the progression within phases don’t align with how healing unfolds in the body.